Home » Pig Model Obesity

Pig Model Obesity

OverWeightF2Pig

The main objectives of this PhD project (funded by the University of Copenhagen for 3 years from 2011-2014) are to 1) estimate heritabilities and genetic correlations for obesity, metabolic syndrome and diabetes (OMSD) traits, 2) conduct genome-wide association study (GWAS) studies and Linkage and Linkage Disequilibrium (LLD) mapping in pigs, 3) conduct candidate gene association analyses and 4) perform comparative systems biology of pig-human

The novel and unique aspect of this PhD project is to integrate datasets at different levels of biological organisation (from genome through transcriptome to phenome) in order to improve the power and accuracy of detecting causal mutations-genes and their functional pathways related to OMSD.

The main achievements of the project would be the discovery of causal genes, networks and biological-metabolic pathways and drug targets in humans. The impact of this innovation will be improved human health and wellbeing